Endoscopic and pathological features and risk factors for early esophageal cancer combined with multiple primary cancer
10.3760/cma.j.cn321463-20231204-00430
- VernacularTitle:早期食管癌合并多原发癌的内镜和病理特征及危险因素分析
- Author:
Haoxi LIU
1
;
Qian ZHANG
1
;
Yang ZHANG
1
;
Changhao ZHANG
1
;
Jie XING
1
;
Peng LI
1
;
Shutian ZHANG
1
Author Information
1. 首都医科大学附属北京友谊医院消化科 消化健康全国重点实验室 国家消化系统疾病临床医学研究中心 北京市消化疾病中心 消化疾病癌前病变北京市重点实验室，北京100050
- Publication Type:Journal Article
- Keywords:
Risk factors;
Early esophageal cancer;
Multiple primary cancer
- From:
Chinese Journal of Digestive Endoscopy
2025;42(2):125-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the endoscopic and pathological features and the independent risk factors for early esophageal cancer combined with multiple primary cancer.Methods:Endoscopic and pathological features of 324 patients diagnosed as having early esophageal cancer from January 2013 to January 2022 in Beijing Friendship Hospital were retrospectively collected. Independent risk factors for early esophageal cancer combined with multiple primary cancer were selected by multivariate logistic regression analysis.Results:Among the 324 patients with early esophageal cancer, 47 (14.51%) patients (29 metachronous and 18 synchronous) had multiple primary cancer. Multivariate logistic regression analysis showed that alcohol drinking ≥5 standard drinks/day ( OR=6.23, 95% CI: 2.49-15.57, P<0.001), submucosal layer invasion ( OR=2.80, 95% CI:1.07-7.30, P=0.036), lesion location at lower esophagus ( OR=4.18, 95% CI: 1.98-8.97, P<0.001) and multiple lesions in esophagus ( OR=3.30, 95% CI:1.57-6.92, P=0.002) were independent risk factors for early esophageal cancer combined with multiple primary cancer. Conclusion:Alcohol drinking ≥5 standard drinks/day, submucosal layer invasion, lower lesions location, and multiple lesions in the esophagus are independent risk factors that are more likely to develop multiple primary cancer in patients with early esophageal cancer. It is recommended to prioritize monitoring patients with these factors, and enhance endoscopic follow-up and assessment.
