Latest progress and prospect of NRP-1 targeted molecular probes for breast cancer diagnosis
10.19401/j.cnki.1007-3639.2025.02.012
- VernacularTitle:NRP-1靶向分子探针助力乳腺癌诊断的最新进展及展望
- Author:
Shuyue CAI
1
;
Quan XIE
;
Yuxuan ZHOU
;
Qingzhu LIU
;
Ling QIU
;
Jianguo LIN
Author Information
1. 南京医科大学药学院,江苏 南京 211166;国家卫生健康委员会核医学重点实验室,江苏省分子核医学重点实验室,江苏省原子医学研究所,江苏 无锡 214063
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Neuropilin-1(NRP-1);
Tumor diagnosis;
Molecular imaging;
Molecular probes
- From:
China Oncology
2025;35(2):249-254
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is one of the most prevalent malignant tumor in women worldwide,in which,triple-negative breast cancer(TNBC)is highly invasive and metastatic.In recent years,the incidence rate of TNBC has gradually increased and shown a trend of younger age.With the in-depth research on the molecular mechanism of breast cancer,neuropilin-1(NRP-1),a transmembrane protein,has been found to be associated with metastasis and prognosis of breast cancer,particularly TNBC.Therefore,NRP-1 has become a promising target for the diagnosis and treatment of breast cancer.The expression and distribution of NRP-1 in breast cancer can be detected by nuclear medicine,optical imaging and multimodal imaging methods in a non-invasive,real-time and accurate manner,which has significant application value in the early diagnosis,staging,treatment,and prognosis evaluation of breast cancer.Nuclear medicine probes specifically target tumor cells or tissues by combining radionuclides(e.g.,68Ga and 99mTc)with specific molecular ligands,and the signal is captured using positron emission tomography(PET)or single-photon emission computed tomography(SPECT),allowing for sensitive diagnosis of breast cancer.With the development of medical imaging and other interdisciplinary subjects,the NRP-1 targeted multimodal molecular probe[68Ga]Ga-NODAGA-K(Cy5)DKPPR combined the high sensitivity of PET with the high resolution advantage of near-infrared fluorescence(NIRF)to achieve precise diagnosis of breast cancer and provide real-time fluorescence navigation during surgery,enhancing the accuracy of tumor tissue identification and excision.In this paper,the advantages and disadvantages of NRP-1 targeted molecular probes in the diagnosis of breast cancer were systematically compared,and the application scope and latest research progress of various probes in the diagnosis and treatment of breast cancer were described,in order to provide reference for the development and clinical application of breast cancer targeted molecular probes.
