Research advances on the application of exosomal multi-omics analysis technology in warning and diagnosis of burn sepsis
10.3760/cma.j.cn501225-20250512-00222
- VernacularTitle:外泌体多组学分析技术在烧伤脓毒症预警与诊断中应用的研究进展
- Author:
Yuxi CHEN
1
;
Liang LUO
1
;
Shiqing JIANG
1
;
Yunchuan WANG
1
;
Dahai HU
1
Author Information
1. 空军军医大学第一附属医院全军烧伤中心，烧伤与皮肤外科，西安 710032
- Publication Type:Journal Article
- Keywords:
Burns;
Sepsis;
Exosomes;
Diagnosis;
Systems biology;
Biomarkers
- From:
Chinese Journal of Burns
2025;41(7):698-703
- CountryChina
- Language:Chinese
-
Abstract:
As one of the primary causes of death in burn patients, sepsis presents challenges in early warning and diagnosis, mainly due to its nonspecific clinical manifestations and the limitations of traditional biomarker detection efficiency. As an important carrier of intercellular information transfer, exosomes and their contents (RNAs, proteins, and metabolites) can reflect the pathophysiological status of the body, thus attracting significant attention in the field of disease diagnosis. This review aims to summarize the research advances of exosomal multi-omics (transcriptomics, proteomics, metabolomics, etc.) analysis technologies in the warning and diagnosis of burn sepsis, and explore their application potential in revealing disease mechanisms, screening specific early biomarkers, and integrating emerging bioinformatics technologies. The goal is to provide new strategies and directions for achieving the precision diagnosis and treatment of burn sepsis.
