Severe liver injury and thrombocytopenia induced by edaravone
10.3760/cma.j.issn.1008-5734.2015.04.014
- VernacularTitle:依达拉奉致严重肝损伤及血小板减少
- Author:
Yanfang CHEN
1
;
Xia FENG
1
;
Ruolun WANG
1
Author Information
1. 510260,广州医科大学附属第二医院药学部
- Publication Type:Journal Article
- Keywords:
Drug-induced liver injury;
Thrombocytopenia;
Edaravone
- From:
Adverse Drug Reactions Journal
2015;(4):300-301
- CountryChina
- Language:Chinese
-
Abstract:
A 47-year-old man received an IV infusion of edaravone 30 mg twice daily for acute cerebral infarction. Three days later,the patient developed yellowish sclera. Laboratory examination showed the following levels:aspartate aminotransferase(AST)269 U/ L,alanine aminotransferase(ALT)1 944 U/ L,γ-glutamyl transpeptidase( γ-GT)133 U/ L,total bilirubin( TBil)100. 01 μmol/ L,and platelet count 70 × 109 / L. The patient was diagnosed as severe liver injury and thrombocytopenia due to edaravone injection. Edaravone was stopped and an IV infusion of polyene phosphatidylcholine 465 mg once daily was given. Seven days later,the patientˊs yellowish sclera disappeared. Laboratory examination showed AST 44 U/ L,ALT 187 U/ L,γ-GT 148 U/ L,TBil 25. 4 μmol/ L,and platelet count 121 × 109 / L. Twelve days later,reexaminations showed AST 39 U/ L,ALT 77 U/ L,and γ-GT 126 U/ L.
