Bilateral median nerve injuries after chemotherapy with paclitaxel and carboplatin
10.3760/cma.j.issn.1008-5734.2015.04.017
- VernacularTitle:紫杉醇联合卡铂化疗致双侧正中神经损害
- Author:
Shuiyuan YANG
1
;
Hong WU
;
Siyu ZENG
;
Yanli TONG
;
Qinghua MEI
Author Information
1. 广东省第二人民医院药学部, 广州,510317
- Publication Type:Journal Article
- Keywords:
Paclitaxel;
Carboplatin;
Median nerve injury
- From:
Adverse Drug Reactions Journal
2015;(4):306-307
- CountryChina
- Language:Chinese
-
Abstract:
A 50-year-old female patient with serious borderline tumor received chemotherapy with paclitaxel and carboplatin(an IV infusion of paclitaxel 198 mg and carboplatin 395 mg on the first day of treatment,the cycle of treatment was 21 d)after undergoing total hysterectomy,bilateral ovarian,and greater omentum resection. After the IV infusion of third chemotherapy cycle,the patient developed persistent and progressive numbness and pain of fingers which could radiate to the elbow. After treatment with carbamazepine and mecobalamin,the symptoms were not relieved. Thus it was considered that the adverse reactions may be caused by chemotherapy drugs. So the chemotherapy was paused temporarily,and prednisone,rebamipide,mouse nerve growth factor for injection,and mecobalamin were given. After 14 d of treatments,the patientˊ s symptoms were alleviated apparently. At half a year of follow-up,the patient developed slight atrophy in the right thenar muscle and hypoesthesia in bilateral index finger and middle finger palm.
