Research advances on the application of skin organoids in wound repair
10.3760/cma.j.cn501225-20240901-00323
- VernacularTitle:皮肤类器官在创面修复中的应用研究进展
- Author:
Siyuan ZHAO
1
;
Wei LI
1
;
Weishi KONG
1
;
Dingding GUAN
1
;
Yu SUN
1
Author Information
1. 海军军医大学第一附属医院烧创伤与创面修复科，全军烧伤研究所，中国医学科学院烧伤暨烧创复合伤救治关键技术创新单元，上海 200433
- Publication Type:Journal Article
- Keywords:
Skin;
Organoids;
Tissue engineering;
Regenerative medicine;
Skin appendage;
Wound repair
- From:
Chinese Journal of Burns
2025;41(7):703-707
- CountryChina
- Language:Chinese
-
Abstract:
Skin is an organ with complex structure and function. Extensive skin defects and chronic non-healing wounds cause serious problems for patients and clinicians, while traditional repair methods are still not able to completely reconstruct the structure and function of skin. To achieve complete reconstruction of skin structure and function is a great challenge that needs to be solved in the field of wound repair. Induced pluripotent stem cells, which have the potential to differentiate into any human cells, are widely used in the field of regenerative medicine research. In recent years, skin organoids constructed through in vitro cultivation of stem cells contain epidermis, dermis, and multiple skin appendages, which overcomes the limitations of traditional skin substitute and opens new avenues for wound repair and its basic research. This review outlines the status of the research and application of skin organoids and discusses their current challenges in clinical translation and prospects for development.
