Research progress of multiplex immunofluorescence in the tumor microenviron-ment of diffuse large B-cell lymphoma
10.13315/j.cnki.cjcep.2025.02.016
- VernacularTitle:多重免疫荧光在弥漫大B细胞淋巴瘤微环境中的研究进展
- Author:
Wenxin TIAN
1
;
Yan LI
Author Information
1. 新疆医科大学研究生学院,乌鲁木齐 830001
- Publication Type:Journal Article
- Keywords:
diffuse large B-cell lymphoma;
multiplex immunofluorescence;
tumor microenvironment
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(2):233-237,241
- CountryChina
- Language:Chinese
-
Abstract:
Diffuse large B-cell lymphoma(DLBCL)is an aggressive disease that exhibits high heterogeneity in terms of biology,clinical manifestations,and prognosis.The tumor microenvironment(TME)plays a crucial role in supporting tumor cell survival.Exploring the TME is of great significance for revealing the occurrence and development of DLBCL,guiding clinical treatment,and predicting prognosis.Multiplex immunofluorescence(mIF)is one of the methods for investigating the TME.mIF can directly perform staining and labeling on tissue sections,retaining the orig-inal spatial structure of DLBCL tissues.mIF not only quantifies the expression levels of markers but also relatively ac-curately identifies the types of different cells,revealing the spatial distribution and interactions of various cells.In addi-tion,its exploration of the expression and role of immune checkpoints cannot be ignored.In this review,the current ap-plication of mIF in DLBCL TME studies is reviewed,which provides a broader perspective for the characterization of DLBCL TME and opens up new ideas for exploring potential therapeutic targets and prognostic markers in DLBCL pa-tients.
