Research progress on the role and related mechanisms of small integral membrane proteins encoded by lncRNAs in tumors
10.13315/j.cnki.cjcep.2025.02.015
- VernacularTitle:lncRNA编码的小整合膜蛋白SMIMs在肿瘤中的作用及相关机制的研究进展
- Author:
Shiting ZHANG
1
;
Rumeng BAI
1
;
Jingjiao XIAO
1
;
Shuning SUN
1
;
Zhihong ZHANG
1
Author Information
1. 南京医科大学第一附属医院病理科,南京 210029
- Publication Type:Journal Article
- Keywords:
neoplasms;
SMIMs;
mitochondrial metabolism;
MAPK;
PI3K/AKT
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(2):228-232
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNAs(lncRNAs)regulate gene expression at the transcriptional,post-transcription-al,or epigenetic levels,and play crucial roles in tumor cell proliferation,invasion,apoptosis,and metabolism.With ongoing research,an increasing number of human microproteins encoded by lncRNAs have been discovered,although their complete functional characterization remains to be explored.This article reviews the research progress on the func-tions and partial mechanisms of the small integral membrane protein(SMIM)family encoded by lncRNAs in tumor ini-tiation and progression.
