Clinicopathological analysis of 8 cases of pulmonary intravascular large B-cell lymphoma
10.13315/j.cnki.cjcep.2025.02.013
- VernacularTitle:肺血管内大B细胞淋巴瘤8例临床病理学分析
- Author:
Chunping LIU
1
;
Yingying GU
1
Author Information
1. 广州医科大学附属第一医院病理科/广州呼吸健康研究院呼吸病理中心,广州 510163
- Publication Type:Journal Article
- Keywords:
intravascular large B-cell lymphoma;
pulmonary disease;
clinicopathological features;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(2):215-220
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate clinicopathological features and differential diagnosis of pulmonary intravascu-lar large B-cell lymphoma(IVLBCL).Methods The clinical data of 8 cases with pulmonary IVLBCL were collected.HE and immunohistochemical EnVision two-step staining methods were used to observe histological features and immu-nophenotypes based on related literature.Results Four cases were male and four cases were female.The ages of the patients ranged from 45 to 67 years,with an average age of(51.25±8.6)years.The main clinical symptoms were fe-ver,cough,and shortness of breath.Serum lactate dehydrogenase,Fe protein,plasma D-dimer,and erythrocyte sedi-mentation rate were all elevated.CT and PET/CT often showed diffuse ground glass opacities in both lungs.Microscop-ic observations showed morphological findings were similar in the eight cases.Tumor cells located in small lumina of alveolar septa,leading to widening of the alveolar septum.The tumor cells were large,prominent nucleoli and high mi-tosis.Immunohistochemistry showed that all cases were positive for CD20,CD79a and PAX-5.Seven cases were non germinal cell phenotype(non-GCB),and one case was germinal cell phenotype(GCB).One case was double expres-sion lymphoma,and three cases were CD5 positive.Ki67 proliferation index was 60％to 80％.Conclusion Pulmo-nary IVLBCL is rare and characterized by selective growth of lymphoma cells within blood vessels.This tumor lacks typical clinical symptoms and is often misdiagnosed as interstitial pneumonia.Therefore,pathologists should raise awareness,make correct diagnoses,and receive early treatment to prolong patient survival.
