Severe intestinal perforation due to bevacizumab
10.3760/cma.j.issn.1008-5734.2015.04.020
- VernacularTitle:贝伐珠单抗致严重肠穿孔
- Author:
Jingpu XU
1
;
Wei KONG
;
Wenting DAI
;
Liya ZHENG
;
Changfang FU
Author Information
1. 河北医科大学第二医院药学部, 石家庄,050000
- Publication Type:Journal Article
- Keywords:
Bevacizumab;
Intestinal perforation
- From:
Adverse Drug Reactions Journal
2015;(4):310-311
- CountryChina
- Language:Chinese
-
Abstract:
A 65-year-old female patient was given treatment scheme of bevacizumab(0. 386 g,the first day),oxaliplatin(150 mg,the first day)and capecitabine(1 g,twice daily,the first day to the 14th day)for colon cancer with liver metastasis. Twenty-three days after administration,the patient developed upper abdominal pain. She was diagnosed of gastrointestinal perforation and diffuse peritonitis by abdominal X-ray and CT scan. Emergency exploratory laparotomy was performed and a perforation with a size about 5 cm × 2 cm was found at the location of ascending colon 5 cm away from ileocecus. Then an ascending colon and terminal ileum fistula operation was performed. After the patientˊs condition was stable,she was given oxaliplatin and capecitabine to continue treatment.
