Elevated serum urea and amylase following tigecycline
10.3760/cma.j.issn.1008-5734.2015.04.021
- VernacularTitle:替加环素致血清尿素和淀粉酶增高
- Author:
Yugui HAO
1
;
Fanfan YI
1
;
Wenwei CHENG
1
Author Information
1. 277101,山东枣庄市立医院急救中心
- Publication Type:Journal Article
- Keywords:
Tigecycline;
Urea;
Amylases
- From:
Adverse Drug Reactions Journal
2015;(4):312-313
- CountryChina
- Language:Chinese
-
Abstract:
A 73-year-old woman with chronic bronchitis, pulmonary interstitial fibrosis, bronchiectasis concurrent infection received an IV infusion of levofloxacin 0. 4 g once daily. One week later, her symptoms were not improved. An IV infusion of tigecycline 50 mg twice daily was added to her regimen according to sputum culture results and drug sensitivity test. Nine days later,the patient developed nausea and vomiting. Laboratory tests showed serum urea value of 36. 5 mmol/ L and amylase 1 166 U/ L. Tigecycline was replaced by IV infusion of imipenem and cilastatin sodium 1. 0 g thrice daily,and levofloxacin continued. Octreotide acetate and pantoprazole sodium were given. Fasting and fluid supplement were applied. One week later,the nausea and vomiting disappeared. Her serum urea and amylase were 8. 1 mmol/ L and 42 U/ L,respectively.
