Hypomagnesemia induced by cetuximab
10.3760/cma.j.issn.1008-5734.2015.04.022
- VernacularTitle:西妥昔单抗致低镁血症
- Author:
Wentong FANG
1
;
Can LUO
1
Author Information
1. 江苏省人民医院药学部, 南京,210029
- Publication Type:Journal Article
- Keywords:
Cetuximab;
Hypomagnesemia
- From:
Adverse Drug Reactions Journal
2015;(4):313-314
- CountryChina
- Language:Chinese
-
Abstract:
A 62-year-old male patient received an IV infusion of cetuximab( cycle 1:716 mg, cycle 2-34:447. 5 mg)once weekly since July 19th,2012 for postoperative anastomotic recurrence of rectal cancer and liver metastasis. Blood magnesium was 0. 35 mmol/ L and other electrolyte levels,biochemical indexes,aldosterone level,thyroid function tests,blood routine,urine routine and stool routine tests were normal when he was admitted to hospital on March 28,2013. Review patientsˊ medical records,blood magnesium level was gradually reduced and accompanied with the application of cetuximab, blood magnesium was 0. 51 mmol/ L on January 31,2013. It was considered that the cetuximab induced hypomagnesemia. An intravenous infusion of magnesium sulfate 10 ml plus 0. 9% sodium chloride 500 ml once daily was given. On day 3,the blood magnesium was 0. 54 mmol/ L,and cetuximab 447. 5 mg was given,he was discharged. Magnesium sulfate was given in outpatient clinic. Eight days later,his blood magnesium was 0. 82 mmol/ L.
