Study on the electroencephalogram characteristics and source localization of alcohol craving based on P300 potential
10.3760/cma.j.cn113661-20210325-00123
- VernacularTitle:基于P300的酒精渴求相关脑电特征及溯源研究
- Author:
Hongdu DENG
1
;
Bingyu ZHANG
;
Junjun ZHANG
;
Jiali WANG
;
Wei HAO
;
Chuansheng WANG
Author Information
1. 新乡医学院第二附属医院 453002
- Publication Type:Journal Article
- Keywords:
Event-related potentials, P300;
Alcohol dependence;
Brain source localization;
Alcohol cue reactivity;
Craving
- From:
Chinese Journal of Psychiatry
2021;54(6):447-454
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to explore the event-related potentials (ERPs) response to alcohol visual cues and their correlations with subjective craving in patients with alcohol dependence (AD) and to search for brain source regions associated with alcohol craving.Methods:Twenty male inpatients with AD were recruited as alcohol-dependent group and 18 healthy men as the control group. ERPs evoked by visual Oddball paradigm containing alcohol cues were tested in both groups and standardized low-resolution brain electromagnetic tomography (sLORETA) was used for brain source localization of ERPs-P300.Visual Analogue Scale (VAS) and Penn Alcohol Craving Scale (PACS) were used for subjective craving assessment. Difference analysis of ERPs data in two groups was performed by mixed-design analysis of variance. The permutation test was used to analyze the difference between two groups of brain source localization. Spearman correlation analysis was conducted between ERPs data, drinking habits, and scale data.Results:Compared with the control group, the alcohol-dependent group showed significantly longer P300 peak latency ( F=9.32, P=0.004) and higher P300 amplitude ( F=20.59, P<0.01; F=14.74, P<0.01) of Fz/Cz when viewing alcohol cues images, and P300 brain source regions were significantly more active in the bilateral dorsolateral prefrontal cortex and right superior parietal lobule ( P<0.01). In the alcohol-dependent group, alcohol cues images evoked significantly longer P300 peak latency ( F=33.82, P<0.01) and higher P300 amplitude ( F=12.56, P=0.001; F=10.92, P=0.002) of Fz/Cz than fruit images, and P300 brain source regions were significantly more active in the left insular cortex and right parahippocampal gyrus ( P<0.01). The P300 amplitude evoked by alcohol cues was positively correlated with VAS and PACS scores ( r s=0.590, P=0.048; r s=0.780, P<0.01). Conclusion:ERPs evoked by visual alcohol cues may help to objectively evaluate craving-related psychology in patients with AD. The bilateral dorsolateral prefrontal cortex, right inferior parietal lobule, left insular cortex, and right parahippocampal gyrus may be related to alcohol craving.
