A preliminary observation of spontaneous neural activities and resting-state functional connectivity in patients with obsessive-compulsive disorder
10.3760/cma.j.cn113661-20210117-00028
- VernacularTitle:静息状态下强迫症患者脑自发神经活动和功能连接的初步观察
- Author:
Dan LYU
1
;
Ping LI
;
Yunhui CHEN
;
Tinghuizi SHANG
;
Lei SUN
;
Cuicui JIA
;
Guangfeng ZHANG
;
Yuhua WANG
;
Zhenghai SUN
;
Yu GUO
;
Wanqiang LIU
Author Information
1. 齐齐哈尔医学院精神卫生学院精神卫生研究所 161006
- Publication Type:Journal Article
- Keywords:
Obsessive-compulsive disorder;
Orbitofrontal cortex;
Fractional amplitude of low-frequency fluctuations;
Functional connectivity
- From:
Chinese Journal of Psychiatry
2021;54(6):440-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the spontaneous neural activities and the whole-brain functional connectivity(FC) patterns at rest in patients with obsessive-compulsive disorder (OCD).Methods:40 drug-naive patients with OCD matched the diagnostic criteria of ICD-10 (OCD group), and 38 genders, age, education-matched healthy controls (controls group) underwent resting-state functional magnetic resonance imaging scan. The fractional amplitude of low-frequency fluctuations (fALFF) approach was used to explore spontaneous neural activities. The brain region with abnormal fALFF value (right orbitofrontal cortex (OFC)) was used as the interested region to carry out the whole-brain FC analysis. We analyzed the correlation of clinical symptoms with the abnormal fALFF and FC values by partial correlation analysis in patients with OCD.Results:Compared with controls group, increased fALFF were found in the right OFC and right dorsolateral prefrontal gyrus ( t=4.45, 5.25; P<0.05, GRF corrected), and increased FC were observed between the right OFC and left OFC, and left cerebellum crus Ⅱ ( t=5.39, 4.94; P<0.05, GRF corrected) in OCD group. The increased FC between right OFC and left cerebellum crus Ⅱ positively correlated with 17-Items Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale scores ( r=0.401, P=0.015; r=0.389, P=0.019; uncorrected). Conclusions:The local spontaneous neural activities and FC in the cortical-striatal-thalamic-cortical and OFC-cerebellar circuits were abnormal at rest in patients with OCD.
