Nodal follicular helper T-cell lymphoma,follicular type:a clinicopathological a-nalysis of 7 cases
10.13315/j.cnki.cjcep.2025.02.009
- VernacularTitle:淋巴结滤泡辅助T细胞淋巴瘤滤泡型7例临床病理学分析
- Author:
Wangyang TANG
1
;
Jianchao WANG
;
Lihua ZHONG
;
Wenfang ZHANG
;
Qiong ZHU
;
Yanping CHEN
;
Gang CHEN
Author Information
1. 浙江大学医学院附属邵逸夫医院病理科,杭州 310000;福建医科大学附属肿瘤医院/福建省肿瘤医院病理科,福州 350014
- Publication Type:Journal Article
- Keywords:
lymphoma;
nodal follicular helper T-cell lymphoma;
follicular type;
angioimmunoblastic type
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(2):191-197
- CountryChina
- Language:Chinese
-
Abstract:
Purpose This study aims to analyze the clinical,pathological,and molecular genetic characteristics of nodal follicular helper T-cell lymphoma,follicular type(nTFHL-F).Methods 7 cases of nTFHL-F were re-viewed.Clinical data were collected,tissue morphology was summarized,and immunohistochemical staining and mo-lecular testing were performed.Results The median age of patients was 62 years with a male-to-female ratio of 6:1.The initial symptoms included neck lymphadenectasis in 6 cases and abdominal discomfort in one.Six cases were in ad-vanced stages,while 1 case was in the localized stage.The tumors exhibited a vague,irregular follicular nodular pat-tern,without significant polymorphic inflammatory background or high endothelial vascular proliferation.Five cases showed a progressive transformation resembling germinal center pattern,and two cases exhibited a follicular lymphoma-like growth pattern.Tumor cells presented three distinct morphologies:centrocyte-like appearance,monocytoid B cell-like appearance,and atypical cells with abundant,transparent cytoplasm.Tumor cells expressed at least three follicu-lar T-cell markers.Testing for ITK::SYK gene fusion was negative in all cases(0/7).Next generation sequencing i-dentified mutations in TET2 gene in two cases(2/2),the RHOA gene in one case(1/2),and VAV1 gene in one case(1/2).The follow-up duration ranged from 2 to 64 months,with three deaths(3/7),and a median survival time of 37 months.Conclusion nTFHL-F predominantly occurs in middle-aged to elderly males,presenting with advanced clinical stages,and has a poor prognosis.nTFHL-F is closely associated with nodal follicular helper T-cell lymphoma,angioimmunoblastic type,and mya coexist within the same individual.
