Progress on the pathogenesis of bipolar disorder based on induced pluripotent stem cells technology
10.3760/cma.j.cn113661-20210104-00019
- VernacularTitle:诱导性多能干细胞技术探索双相障碍发病机制的研究进展
- Author:
Xiaoyu LIU
1
;
Aihua YUAN
1
;
Yiru FANG
1
Author Information
1. 上海交通大学医学院附属精神卫生中心 临床研究中心 200030
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Induced pluripotent stem cells;
Pathogenesis
- From:
Chinese Journal of Psychiatry
2021;54(5):390-395
- CountryChina
- Language:Chinese
-
Abstract:
Bipolar disorder (BD) has become one of the leading causes of healthy burdens globally, but the pathogenesis has not been fully understood due to the lacking of accurate and reliable research methods. Recently, the induced pluripotency stem cells (iPSCs) technology has been used to explore the mechanisms of psychiatric diseases, including bipolar disorder. Through the establishment of in vitro BD neuronal cell models with same genetic information as the patient donors, some pathogenic clues that were reported previously have been observed and validated. These clues are neurodevelopmental defects, ion channels dysfunctions, mitochondrial dysfunctions, abnormalities in phosphorylation of CRMP2, abnormal expressions of miRNA and dysfunctions of immune inflammatory procedures. Although a lot of problems and limitations need to be resolved and improved, iPSCs has great value in basic medicine researches and clinical applications because it can be based on clinical samples to establish the in vitro neuronal cell models of bipolar disorder. IPSC-derived in vitro BD models is expected to break through the bottleneck and eventually promote the pathological studies and new treatments in psychiatry.
