EBV-positive nodal T-and NK-cell lymphoma:an analysis of 5 cases with clinico-pathological features
10.13315/j.cnki.cjcep.2025.02.008
- VernacularTitle:EBV阳性淋巴结T/NK细胞淋巴瘤5例临床病理特征
- Author:
Yongta HUANG
1
;
Wenwen GUO
1
;
Xia LIU
1
;
Ling LI
1
;
Qiurong YE
1
;
Xianglan MO
1
Author Information
1. 广西壮族自治区人民医院(广西医学科学院)病理科,南宁 530021
- Publication Type:Journal Article
- Keywords:
lymphoma;
T/NK cells;
EBV;
EBER;
in situ hybridization
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(2):186-190
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the clinicopathological features of EBV-positive nodal T-and NK-cell lymphoma.Methods Clinical and pathological data of 5 cases were collected.The expression of CD3,CD56,TIA-1,Granzyme B and other markers were detected by immunohistochemistry.The expression of EBER was detected by in situ hybrid-ization.The gene rearrangement and clonality were analyzed by PCR and polyacrylamide gel electrophoresis.The litera-tures were reviewed.Results The primary lesions of the 5 patients were all located in lymph nodes.All patients pres-ented with multiple lymphadenopathy,B symptoms,elevated lactate dehydrogenase(LDH)and C-reactive protein(CRP),and were in stage Ⅲ/Ⅳ.Histopathologically,the lesions show a diffuse infiltration of large to medium monot-onous tumor lymphocytes.Cell apoptosis,necrosis,and vascular invasion were not significant.Tumor cells of all cases were positive for CD3 but negative for CD56.All cases were positive for the cytotoxic markers.In situ hybridization de-tection showed that the majority of tumor cells were diffusely positive for EBER.Nevertheless,only 4 cases were posi-tive for TCR gene clonal rearrangement.Three patients received chemotherapy,2 patient declined the treatments.The median overall survival was only 3 months.Conclusions EBV-positive nodal T-and NK-cell lymphoma is an EBV-positive lymphoma of cytotoxic T-or NK-cell lineage presenting primarily with nodal disease,which is more common in elderly males.The patient has obvious symptoms and signs,rapid disease progression,and poor prognosis.Under-standing the clinicopathological features of EBV-positive nodal T-and NK-cell lymphoma can help differentiate it from other EBV-positive T-and NK-cell lymphoid proliferations and lymphomas.
