Precision diagnosis of large B-cell lymphoma
10.13315/j.cnki.cjcep.2025.02.003
- VernacularTitle:大B细胞淋巴瘤的精准病理诊断
- Author:
Yunfei SHI
1
;
Xianghong LI
1
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所病理科/恶性肿瘤发病机制及转化研究教育部重点实验室,北京 100142
- Publication Type:Journal Article
- Keywords:
diffuse large B-cell lymphoma;
pathological diagnosis;
molecular pathology;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(2):149-156
- CountryChina
- Language:Chinese
-
Abstract:
Large B-cell lymphoma(LBCL),formerly known as diffuse large B-cell lymphoma(DLBCL),is the most common type of lymphoma,characterized by high invasiveness and strong heterogeneity.The World Health Organ-ization(WHO)lymphoma classification has been continually updated to better differentiate the biological behaviors of various subtypes of DLBCL.These updated classifications are increasingly important for prognosis stratification and treatment decisions for oncologists.The increasingly refined classification of DLBCL will inevitably require pathologists to make more precise diagnoses.Furthermore,the advances and growing diversity in lymphoma treatment also create a demand for precision diagnosis in LBCL,including therapy-target evaluation.Based on our own experience,we have systematically reviewed and summarized the current knowledge and progress in precision diagnosis of LBCL.This re-view aims to emphasize the importance of precision diagnosis in LBCL,help readers understand the relevant concepts more comprehensively and accurately,and promote the adoption of more reasonable diagnostic procedures.
