The mechanism and application prospects of mitochondrial quality control in osteoarthritis
10.12092/j.issn.1009-2501.2025.02.016
- VernacularTitle:线粒体质量控制在骨关节炎中的作用机制及应用前景
- Author:
Liang WANG
1
;
Yinshuan DENG
;
Tao QU
;
Chaoming DA
;
Yunfei HE
;
Rui LIU
;
Weimin NIU
;
Weishun YAN
;
Zhen CHEN
;
Shuo LI
;
Zhiyun YANG
;
Binbin GUO
;
Xueqian LAI
Author Information
1. 甘肃省中心医院骨科,兰州 730070,甘肃
- Publication Type:Journal Article
- Keywords:
osteoarthritis;
mitochondria;
mecha-nism;
review
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(2):282-288
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis(OA)is a common joint disease in clinical practice,and cartilage damage is a typical pathological change.The pathogenesis of OA is complex,and various adverse factors can lead to the occurrence of OA.Mitochondria are im-portant organelles within cells and play important roles in cellular physiological and pathological activ-ities.Mitochondrial quality control is an important regulatory mechanism in the body to maintain nor-mal mitochondrial structure and function,mainly including mitochondrial biogenesis,mitochondrial dynamics,mitochondrial autophagy,mitochondrial oxidative stress,and other forms.The imbalance of mitochondrial quality control in chondrocytes is closely related to the occurrence and development of osteoarthritis,and regulating the balance of mi-tochondrial quality control is a potential therapeu-tic point for osteoarthritis.The author reviewed rel-evant research literature in recent years to provide a review of the relationship between mitochondrial quality control and the occurrence and develop-ment of osteoarthritis,in order to provide new ideas and directions for the research and diagnosis and treatment strategies of osteoarthritis.
