Progress in the pharmacological effects of naringin on cardiovascular diseases
10.12092/j.issn.1009-2501.2025.02.015
- VernacularTitle:柚皮苷对心血管疾病的药理作用研究进展
- Author:
Dan LIU
1
;
Jiawei MIAO
1
;
Zihao TAN
1
;
Chunyao HE
1
;
Mingzhu ZHAO
1
;
Xiuzhen HE
1
Author Information
1. 重庆三峡医药高等专科学校三峡库区道地药材开发利用重庆市重点实验室,万州 404120,重庆
- Publication Type:Journal Article
- Keywords:
naringin;
atherosclerosis;
ischemia/reperfusion;
myocardial hypertrophy;
cardiotoxicity
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(2):272-281
- CountryChina
- Language:Chinese
-
Abstract:
Naringin is a flavonoid compound with a wide range of biological and pharmacologi-cal activities,which can be used in treating tumor,diabetes,neurodegenerative diseases,cardiovascu-lar diseases,metabolic syndrome,etc.Among them,the application of naringin in cardiovascular diseases has attracted the attention of many re-searchers.This article mainly reviews the role of naringin in cardiovascular disease(regulating blood lipids,anti atherosclerosis,lowering blood pres-sure,inhibiting myocardial hypertrophy,anti myo-cardial infarction,protecting myocardial ischemia/reperfusion injury,reducing myocardial ischemia/reperfusion injury and improving pulmonary arteri-al hypertension),the protective effect on cardiotox-icity,and the signal pathways in cardiovascular dis-ease(PI3K-Akt-mTOR,p-eNOS/p-Akt/p-ERK,miR-126/GSK-3 β/β-Catenin),clinical trials,etc.This pa-per is expected to review the current research sta-tus of naringin in cells and animal models so as to reveal its clinical application prospects and provide reference for further research in related fields.
