Research progress on the effect of hippocampal FXR regulation of CREB-BDNF signaling pathway on depression

VernacularTitle:基于海马FXR调控CREB-BDNF信号通路影响抑郁症的研究进展
Author: Hui HE ¹ ; Mingliang GUO ¹ ; Licheng RAN ¹ ; Yajun WANG ¹
Author Information

1. 甘肃中医药大学针灸推拿学院,兰州 730000,甘肃
Publication Type:Journal Article
Keywords: FXR; CREB-BDNF; signaling pathway; depression
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2025;30(2):265-271
CountryChina
Language:Chinese
Abstract: Depression is a mental disorder char-acterized by mood disturbances that pose a signifi-cant threat to human mental and physical health.In recent years,the farnesoid X receptor(FXR)has been found to be expressed in brain regions such as the hippocampus and is closely related to the onset of depression.It can also affect the down-stream target cAMP response element binding pro-tein(CREB)-brain-derived neurotrophic factor(BDNF)signaling pathway,holding promise as a new target for the treatment of depression.This ar-ticle analyzes how hippocampal FXR regulates the CREB-BDNF signaling pathway and summarizes the latest research progress related to the pathogene-sis of depression,with the aim of providing precise targeted ideas for the drug development and clini-cal treatment of depression.