Advanced research in tryptophan-kynurenine pathway and its metabolites in depression
10.3760/cma.j.cn113661-20200622-00293
- VernacularTitle:色氨酸-犬尿氨酸代谢途径及其代谢产物在抑郁症中的研究进展
- Author:
Yajun YUN
1
;
Zhiren WANG
;
Huimei AN
;
Qi ZHANG
;
Ting MA
;
Wenxuan ZHAO
;
Yongqian WANG
;
Fude YANG
Author Information
1. 北京大学回龙观临床医学院 北京回龙观医院100096
- Publication Type:Journal Article
- Keywords:
Kynurenine;
Depressive disorder;
Quinolinic acid;
Neuroinflammation
- From:
Chinese Journal of Psychiatry
2021;54(3):233-238
- CountryChina
- Language:Chinese
-
Abstract:
Major depressive disorder is a serious chronic and disabling mental disease, which produces a tremendous family-society economic burden due to its high prevalence, high recurrence rate, and high disability rate. Accumulating evidences demonstrate that abnormalities of the kynurenine pathway may be implicated in the pathophysiology of depression. This review systematically elucidates the role of tryptophan-kynurenine pathway and its bioactive metabolites in depression and explains the potential treatment implications of targeted drugs based on kynurenine pathway, which provides a certain theoretical basis for further exploration of the etiology and pathogenesis in depression.
