Magnetic resonance imaging study of cerebral cortex thicknesses in alcohol dependent patients after acute detoxication
10.3760/cma.j.cn113661-20200716-00336
- VernacularTitle:酒依赖患者急性脱瘾治疗后大脑皮质厚度的磁共振成像研究
- Author:
Kebing YANG
1
;
Qingyan YANG
1
;
Rongjiang ZHAO
1
;
Yajuan NIU
1
;
Ting YU
1
;
Fengmei FAN
1
;
Hongzhen FAN
1
;
Yunlong TAN
1
Author Information
1. 北京回龙观医院 北京大学回龙观临床医学院 100096
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Alcohol dependence;
Cortical thickness
- From:
Chinese Journal of Psychiatry
2021;54(2):119-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the abnormal features of cortical thickness of brain regions in patients with alcohol dependence (PADs) after acute detoxication and the correlation with clinical features of PADs.Methods:In this study, male inpatients with alcohol dependence (patient group, n=33) and healthy controls (control group, n=35) matched with age and education were enrolled during the period of Apr 2017 to Apr 2018. Brain functional magnetic resonance imaging (MRI) data, general demographic and clinical information were collected. FreeSurfer software was used to process the MRI data and compute the bilateral cortical thickness across 74 brain regions. Analysis of covariance (ANCOVA) was performed to analyse the differences of cortical thickness in different brain regions between the two groups, and the correlation between the cortex thickness and their clinical features in PADs was explored by using correlation analysis. Results:Compared with HCs, PADs showed significantly decreased cortical thickness of brain regions in the left middle and pole occipital, right superior occipital gyri, bilateral superior and inferior parietal gyri, and right intraparietal sulcus (all P<0.000 34, after Bonferroni correction). Positive correlation was found between the thickness of left superior parietal gyrus (SPG) and initial drinking age ( r=0.428, P=0.024) in PADs. Conclusion:The cortex thickness reduction of bilateral posterior parietal cortex might be a more characteristic injury in PADs. Furthermore, the initial drinking age may have a more obvious effect on the cortex of the left SPG.
