Correlation between niacin skin flushing and cognitive function in patients with depression
10.3760/cma.j.cn113661-20200803-00354
- VernacularTitle:抑郁症患者烟酸皮肤潮红反应与认知功能的关联分析
- Author:
Ruihua MA
1
;
Yang LUO
;
Panqi LIU
;
Hua GUO
;
Sijia LIU
;
Jing SHI
;
Yunlong TAN
;
Fude YANG
;
Li TIAN
;
Zhiren WANG
Author Information
1. 北京大学回龙观临床医学院 北京回龙观医院 100096
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Cognition;
Niacin skin flushing response
- From:
Chinese Journal of Psychiatry
2021;54(3):204-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between niacin skin reaction sensitivity and cognitive function by comparing the difference of niacin skin flushing response and cognitive function between the patients with depression and the normal control group.Method:A cross-sectional study was conducted to recruit 40 patients with depression who met the diagnostic criteria of DSM-Ⅳ (American Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) at The Second People′s Hospital of Zhumadian from July 2018 to August 2019. In the meanwhile, 32 gender-and-education-matched patients were recruited and allocated into the control group. General demographic and clinical data were collected. Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was used to test individual′s cognitive functions. A Swedish laser Doppler blood flow meter, PeriFlux 5000, was used to test the skin flushing reaction of forearm niacin at eight concentrations (10 -5 mol/L, 10 -4 mol/L, 10 -3.5 mol/L, 10 -3 mol/L, 10 -2.5 mol/L, 10 -2 mol/L, 10 -1.5 mol/L, and 10 -1 mol/L) gradient. The difference of blood flow values in 8 concentration gradients between the two groups was analyzed by repeated measurement multiple comparison and simple effect. The MBF value and LogEC50 were analyzed by non-parametric test. Spearman rank correlation analysis was used to analyze the correlation between LogEC50 and cognitive function scores. Result:In the skin flushing reaction of niacin test, when the concentration of niacin solution was 10 -3.5 mol/L and 10 -3mol/L, there was a significant difference in Blood Flow (BF) between patients with depression and normal subjects ( t=-0.490,-4.626, P<0.01, respectively). The BF value of the normal control group was higher than that of depressed patients. LogEC50 was significantly different between the two groups ( t=4.196, P<0.01). LogEC50 of the normal control group (-3.513±0.848) was lower than that of the depression group (-2.776±0.568). The difference in RBANS between the two groups was tested by independent sample t test. Compared with the normal control group, the scores of the depressed group were significantly lower on the test of list learning ( t=-2.127, P=0.037), coding test ( t=-3.226, P=0, 002), list recall ( t=-3.697, P<0.01), story recall ( t=-2.687, P=0.009), and figure recall ( t=-2.660, P=0.010). There was a negative correlation between list recall ( r=-0.407, P=0.032), story recall ( r=-0.376, P=0.049) and figure recall ( r=-0.455, P=0.015) in the depression group. Maximal blood flow (MBF) was positively correlated with figure copying ( r=0.428, P=0.023). Conclusion:The niacin sensitivity and the score of cognitive function of depression patients are lower than those of the normal control group, and the decrease of cognitive function of depression patients may be related to the disorder of phospholipase A2 (PLA2) signaling pathway.
