Paclitaxel-induced hollow toenail
10.3760/cma.j.issn.1008-5734.2015.05.018
- VernacularTitle:紫杉醇致双足趾甲空洞
- Author:
Jianhui ZHU
1
;
Xiying SHAO
;
Zeng WANG
Author Information
1. 浙江省肿瘤医院药剂科,杭州,324000
- Publication Type:Journal Article
- Keywords:
Paclitaxel;
Nails;
Chemoradiotherapy,adjuvant
- From:
Adverse Drug Reactions Journal
2015;17(5):382-383
- CountryChina
- Language:Chinese
-
Abstract:
A 32-year-old woman with breast cancer received a postoperative adjuvant chemotherapy with epirubicin plus cyclophosphamide followed by paclitaxel.The drug regimen of paclitaxel was intravenous infusion 120 mg once a week.On the day 6 after the first cycle of paclitaxel treatment, the patient developed bilateral big toenail hollowness, the aperture was about 2 mm.She was given the second cycle of paclitaxel according to the original plan.Six days later, the hollow toenail was worsened with slight pain.Paclitaxel was stopped.Mecobalamin, erythromycin ointment and keeping warm of feet were applied.Four days later,the pain was reduced, and the toenail hollowness did not continue to enlarge.
