Research progress on the role of gut microbiota in metabolic side effects caused by the second-generation antipsychotic medications
10.3760/cma.j.cn113661-20201123-00480
- VernacularTitle:肠道微生物在第二代抗精神病药引起代谢不良反应中的作用研究进展
- Author:
Chenchen LIU
1
;
Renrong WU
1
Author Information
1. 中南大学湘雅二医院精神卫生研究所，长沙410011
- Publication Type:Journal Article
- Keywords:
Antipsychotic agents;
Metabolism;
Gut microbiota;
Prebiotics;
Probiotics
- From:
Chinese Journal of Psychiatry
2021;54(5):401-404
- CountryChina
- Language:Chinese
-
Abstract:
Second-generation antipsychotic medications are widely used to treat patients with schizophrenia and other mental disorders, however, second-generation antipsychotic medications could cause metabolic side effects such as weight gain, hyperglycemia, dyslipidemia and insulin resistance. The mechanisms that cause metabolic side effects is still unclear. Until now, there is still a lack of effective treatments of metabolic side effects caused by the second-generation antipsychotic medications. In recent years, many studies have showed that gut microbiota may play an important role. This review focused on the mechanisms of gut microbiota in metabolic side effects caused by the second-generation antipsychotic medications, and the role of probiotics and prebiotics in the prevention or treatment of metabolic side effects.
