Induction of M1/M2 polarization of macrophages by lipopolysaccharides and titanium particles in peri-implant tissues
- VernacularTitle:脂多糖和钛颗粒对种植体周围组织中巨噬细胞M1/M2极化的诱导作用
- Author:
Ran DENG
1
;
Yi WEI
;
Xiaowei JI
Author Information
- Publication Type:Journal Article
- Keywords: peri-implantitis; lipopolysaccharide; titanium particle; TLRs/NF-κB; M1/M2; macrophage
- From: Chinese Journal of Tissue Engineering Research 2025;29(34):7415-7422
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:With the popularization of implant technology,the incidence of peri-implantitis is increasing year by year,but the etiological mechanism is still unclear.Highly plastic macrophages can be polarized into M1 and M2 types under microenvironment stimulation,which play pro-inflammatory and anti-inflammatory effects,respectively,and play an important role in host defense,immune response,and maintenance of internal environment homeostasis in peri-implant tissues.The polarization trend of M1/M2 macrophages is closely related to the balance of foreign body response around implants.OBJECTIVE:Lipopolysaccharide and titanium particles are important pathogenic factors causing peri-implantitis,in order to further explore their inducible effect on macrophage polarization in peri-implant tissues.METHODS:The Chinese keywords were"peri-implantitis,macrophage polarization,lipopolysaccharide,titanium particles."The English keywords were"macrophage polarization,peri-implant inflammation,peri-implantitis,LPS,TLRs,NF-κB."The CNKI and PubMed databases were searched,and the relevant literature was screened and sorted to analyze the induction effect and related mechanism of lipopolysaccharide and titanium particles on M1/M2 polarization of macrophages in peri-implant tissues.RESULTS AND CONCLUSION:(1)Lipopolysaccharide and titanium particles may induce macrophage polarization in peri-implant tissues through Toll-like receptor/nuclear factor κB and other related signaling pathways,causing M1/M2 polarization imbalance and thus affecting the occurrence and progression of peri-implantitis.Some drugs can also regulate macrophage M1/M2 polarization through Toll-like receptor/nuclear factor κB signaling pathway to treat related inflammatory diseases.(2)By analyzing the induction effect of lipopolysaccharide and titanium particles on macrophage M1/M2 polarization in peri-implant tissues,the mechanism of their regulation of Toll-like receptor/nuclear factor κB signaling pathway to induce macrophage polarization is further explained,in order to provide some new ideas and strategies for the study of immune prevention and treatment of peri-implantitis.
