Altered inter- and intrahemispheric functional connectivity dynamics in long-term smokers
10.3760/cma.j.cn113661-20210517-00163
- VernacularTitle:长期吸烟者大脑半球水平动态功能连接密度改变的磁共振成像研究
- Author:
Mengzhe ZHANG
1
;
Huiyu HUANG
1
;
Xinyu GAO
1
;
Zhengui YANG
1
;
Mengmeng WEN
1
;
Weijian WANG
1
;
Jingliang CHENG
1
;
Yong ZHANG
1
Author Information
1. 郑州大学第一附属医院磁共振科，郑州450052
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Smoking;
Functional connectivity density;
Cerebral hemisphere
- From:
Chinese Journal of Psychiatry
2022;55(2):98-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the neuro mechanism of tobacco addiction, this study applied the dynamic functional connectivity density (dFCD) to analyze the dynamic changes of brain functional networks at both whole-brain and hemisphere levels in long-term male smokers.Methods:Thirty-seven smokers met the criteria for substance addiction according to the Diagnostic and Statistical Manual of Mental Disorders-Four Edition (DSM-Ⅳ) and 47 healthy controls matched with age and education were recruited. Resting-state functional magnetic resonance imaging (rs-fMRI) data and clinical data were collected in both smokers and healthy controls. The whole-brain functional connectivity was decomposed into ipsilateral and contralateral functional connectivity. Sliding-window analysis was utilized to capture the intra- and interhemispheric dFCD patterns. The temporal variability of the functional connectivity dynamics was further quantified using the standard deviation (SD) of intra- and inter-hemispheric dFCD over time. The two-sample t-test was used to compare dFCD variance between the two groups. Results:Compared with healthy controls, smokers showed increased global dFCD variance in the left insula and left putamen ( t=3.99, 4.49). Increased dFCD variability was observed in the left insula and left putamen among smokers compared with healthy controls when comparing dFCD variability at both intra-( t=4.20, 4.33) and interhemispheric ( t=3.81, 4.33) level (Gaussian Random Field GRF corrected, voxel P<0.005, cluster P<0.05). Conclusion:Among long-term smokers, a time-varying characteristic of functional connectivity patterns was observed in the left insula and left putamen, which reflects the abnormal communication between these brain areas and other brain areas. The alteration of intra- and interhemispheric dynamic functional connectivity may be the underlying neuro mechanism of tobacco addiction.
