Relationship between abnormal kynurenine metabolism and glucose-insulin level in first-episode schizophrenia
10.3760/cma.j.cn113661-20210126-00046
- VernacularTitle:首次发病精神分裂症患者犬尿氨酸代谢异常及与血糖-胰岛素水平的关系
- Author:
Mingyuan GAN
1
;
Yunlong TAN
1
;
Zhiren WANG
1
;
Shuping TAN
1
Author Information
1. 北京大学回龙观临床医学院 北京回龙观医院 100096
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Kynurenine;
Glucose-insulin metabolism
- From:
Chinese Journal of Psychiatry
2021;54(5):354-362
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the abnormality of kynurenine metabolic pathway and the glucose-insulin level in first-episode schizophrenia.Methods:In this study, a total of 160 first episode patients with schizophrenia and 122 age-, gender-, education-matched healthy controls were recruited. Serum levels of tryptophan, kynurenine, kynurenic acid and quinolinic acid were measured using liquid chromatography-tandem mass spectrometry. Meanwhile, fasting plasma glucose and fasting plasma insulin levels were measured in all subjects. The independent sample t test or Mann Whitney U test were used for comparison between groups. The relationships between fasting plasma glucose-insulin metabolism measures and indexes of kynurenine metabolites were investigated by the bivariate correlation and partial correlation. Results:The first episode patients with schizophrenia had higher levels of fasting plasma glucose (5.5(4.8, 6.4) mmol/L vs. 5.1(4.8, 5.4) mmol/L, Z=-3.93, P<0.01) and lower levels of fasting plasma insulin ((6.2±2.9) pmol/L vs. (7.2±4.0) pmol/L, t=-2.45, P=0.015) than the healthy controls. The levels of tryptophan (11 449.5(10 053.5, 12 828.5) nmol/L vs. 16 780.0 (13 735.0, 18 997.5) nmol/L, Z=-10.69, P<0.01), kynurenine (252.2(208.7, 307.4) nmol/L vs. 637.8 (355.5, 827.4) nmol/L, Z=-11.02, P<0.01), kynurenic acid (5.0(3.7, 6.9) nmol/L vs. 11.0 (8.5, 14.3) nmol/L, Z=-11.48, P<0.01) and quinolinic acid (39.7(31.0, 47.3) nmol/L vs. 53.2(44.7,68.6) nmol/L, Z=-8.29, P<0.01) in the first episode patients with schizophrenia were significantly lower than those in the healthy controls. Furthermore, our results showed that kynurenic acid levels was positive correlated with fasting plasma insulin levels ( r=0.46, P<0.01) in the first episode patients with schizophrenia. Conclusions:The level of kynurenine metabolic pathway in patients with schizophrenia is decreased, which is associated with the risk of hyperinsulinemic glucose metabolism.
