Correlation between stereopsis and cognitive function in first-episode drug-na?ve patients with schizophrenia
10.3760/cma.j.cn113661-20210119-00032
- VernacularTitle:首次发病未服药精神分裂症患者立体视觉与认知功能的相关性研究
- Author:
Luyang GUAN
1
;
Wenlong HOU
1
;
Jiaqi CAO
1
;
Nannan ZHUANG
1
;
Rufeng CHEN
1
;
Xuyuan YIN
1
;
Zhenhua ZHU
1
;
Jing WANG
1
;
Qiufang JIA
1
;
Li HUI
1
Author Information
1. 苏州大学附属广济医院生物精神医学研究中心 215137
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Stereoscopic vision;
Cognitive function;
Clinical symptoms
- From:
Chinese Journal of Psychiatry
2021;54(3):177-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore stereoscopic vision and its correlation with cognitive function in first-episode drug-na?ve patients diagnosed with schizophrenia (FNPS).Methods:A study was conducted from January 2019 to September 2020. A total of 146 FNPS, 124 patients with chronic schizophrenia (PCS) and 101 healthy controls (HCs) were recruited. Stereoscopic vision was evaluated by Titumus stereotests. Their clinical symptoms were assessed by positive and negative syndrome scale. Cognitive function was assessed by the repeatable battery for the assessment of neuropsychological status (RBANS). The differences in stereoscopic vision and cognitive function among the three groups were analyzed by analysis of covariance. The Spearman correlation and multiple regression analysis were used to identify the correlation between stereoscopic vision and clinical symptoms or cognitive function.Results:(1) There were significant differences in stereoscopic vision and cognitive function among the three groups ( P<0.05). After pairwise comparison, it was found that the stereoscopic vision and cognitive functions of FNPS group and PCS group were significantly different from HCs group. However, there were no significant differences in stereoscopic vision and cognitive function between FNPS and PCS groups. (2) Spearman correlation analysis showed that stereoscopic vision was not correlated with the severity of clinical symptoms in FNPS, but it was correlated with visuospatial score ( r=-0.193, P=0.019), language score ( r=-0.261, P=0.001), attention score ( r=-0.168, P=0.042), and RBANS total scores ( r=-0.236, P=0.004). Moreover, there was no correlation of stereoscopic vision with the severity of clinical symptoms or cognitive function in HCs and PCS. Further multiple linear regression showed the significant effect of stereoscopic vision on visuospatial score ( β=-0.213, P=0.011), language score ( β=-0.252, P=0.003), attention score ( β=-0.189, P=0.019), RBANS total score ( β=-0.235, P=0.003) in FNPS. Conclusions:FNPS and PCS show significant impairments in stereoscopic vision and cognitive function. Stereoscopic vision is closely correlated with cognitive function rather than the severity of clinical symptoms in FNPS.
