Three lineage pancytopenia induced by preventive and over course treatment of sodium valproate
10.3760/cma.j.issn.1008-5734.2017.04.013
- VernacularTitle:超疗程预防性服用丙戊酸钠缓释片致三系血细胞减少
- Author:
Hua NI
1
;
Yong YUAN
1
;
Hui LIU
1
;
Wenjing NI
1
;
Wenjin XU
1
Author Information
1. 210006,徐州医科大学附属第二医院康复科
- Publication Type:Journal Article
- Keywords:
Valproic acid;
Pancytopenia
- From:
Adverse Drug Reactions Journal
2017;19(4):296-297
- CountryChina
- Language:Chinese
-
Abstract:
A 56-year-old male patient received sodium valproate 0.5 g/d for prevention of epilepsy because of postoperative cerebral hemorrhage.Thirty-six days later, the results of reexamination showed the following values: white blood cell (WBC) 3.3×109/L, red blood cell (RBC) 3.2×1012/L, hemoglobin (Hb) 100 g/L, platelet count (PLT) 94×109/L.He did not receive any treatments and continued to take sodium valproate at the same dose.One hundred and two days later, the results of reexamination showed the following values: WBC 1.9×109/L, RBC 3.2×1012/L, Hb 90 g/L, PLT 82×109/L.He was diagnosed with 3 lineage pancytopenia.Sodium valproate was withdrawn.The results of reexamination 13 days later showed the following values: WBC 4.3×109/L, RBC 3.5×1012/L, Hb 100 g/L, PLT 109×109/L.
