Changes of cerebral blood flow perfusion in bipolar disorder patients with suicidal ideation: a resting-state functional magnetic resonance imaging study
10.3760/cma.j.cn113661-20200407-00168
- VernacularTitle:伴自杀意念双相障碍Ⅱ型患者脑血流灌注改变的研究
- Author:
Youling PAN
1
;
Feng CHEN
;
Guanmao CHEN
;
Pan CHEN
;
Yanbin JIA
;
Shuming ZHONG
;
Shunkai LAI
;
Jurong WANG
;
Zhenye LUO
;
Guixian TANG
;
Li HUANG
;
Ying WANG
Author Information
1. 暨南大学附属第一医院影像中心，广州 510630
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Suicide;
Arterial spin labeling;
Cerebral brain flow
- From:
Chinese Journal of Psychiatry
2020;53(6):493-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the changes of cerebral blood flow (CBF) in bipolar disorder type Ⅱ patients with and without suicidal ideation.Methods:Pseudo-continuous arterial spin labelling (pCASL) was examined with resting-state functional magnetic resonance imaging(rs-fMRI) on all subjects, CBF images of bipolar disorder type Ⅱ depression with suicidal ideation ( n=48), Bipolar Disorder type Ⅱ without suicidal ideation ( n=41), healthy controls ( n=62) at rest were collected. One-way ANOVA and Gaussian random field (GRF) were used to compare the CBF values between the groups to locate the regions with significant change. Results:Compared with the control group, CBF of left superior temporal gyrus (extending to the temporal pole) ( t=3.87, P<0.01; t=4.44, P<0.01) and left putamen ( t=4.04, P<0.01; t=3.19, P<0.01) increased in bipolar disorder type Ⅱ patients with and without suicidal ideation, and CBF of the right posterior cingulate gyrus (extending to the calcarine gyrus) decreased in bipolar disorder type Ⅱ patients with suicidal ideation( t=-4.66, P<0.01). Conclusions:There were abnormal CBF in left superior temporal gyrus and left putamen in bipolar disorder type Ⅱ patients with suicidal ideation and bipolar disorder type Ⅱ patients without suicidal ideation, while the decreased CBF in right posterior cingulate gyrus may be the specific brain change in bipolar disorder type Ⅱ patients with suicidal ideation.
