Correlation between risk factors of microvascular dysfunction and cognitive impairment in late-life depression
10.3760/cma.j.cn113661-20210120-00033
- VernacularTitle:微血管功能障碍相关危险因素与老年抑郁症患者认知损害的相关分析
- Author:
Huarong ZHOU
1
;
Tianle WANG
;
Xiaomei ZHONG
;
Ben CHEN
;
Zhangying WU
;
Min ZHANG
;
Qiang WANG
;
Naikeng MAI
;
Qi PENG
;
Yuping NING
Author Information
1. 广州医科大学附属脑科医院精神神经科学研究所 510370
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Aged;
Cognition;
Microvascular function
- From:
Chinese Journal of Psychiatry
2021;54(4):252-258
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between risk factors of microvascular dysfunction and cognitive impairment in Late-life depression (LLD).Methods:From May 2014 to May 2019, a total of 89 healthy elderly people (normal control group) and 113 patients with LLD (LLD group) were recruited. Patients with LLD were divided into normal cognition group ( n=33) and mild cognitive impairment (MCI) group ( n=80). The related medical history of microvascular dysfunction (e.g. hypertension, type 2 diabetes, coronary heart disease and hyperlipidemia), plasma concentration of homocysteine and C-reactive protein, and MRI features of cerebral small vessel disease (e.g. white matter hyperintensities, enlarged perivascular space and lacunar infarction) were collected or detected. All participants completed the comprehensive neuropsychological assessment on global cognition and other cognitive domains. The differences of microvascular function and cognition among the groups were compared. The correlation between microvascular dysfunction related biomarkers and the cognitive scores was further analyzed. Finally, Logistic regression analysis was used to explore the risk factors affecting cognitive impairment in patients with LLD. Results:The proportion of hypertension and the concentration of homocysteine in LLD with MCI group were significantly higher than those in normal control group and LLD with normal cognition group (χ 2=15.67, P<0.01; F=7.05, P=0.001). Enlarged perivascular space in centrum semiovale in LLD with MCI group was more severe than that in normal control group (χ 2=10.64, P=0.005). Both homocysteine ( r=-0.25, P=0.024) and white matter hyperintensities ( r=-0.33, P=0.017) were negatively correlated with executive function in LLD with MCI group. Hypertension (β=2.34, P=0.005), high levels of homocysteine (β=1.74, P=0.039) and increased EPVS in the semi-oval area (β=1.31, P=0.028) were the independent risk factors for cognitive impairment in patients with LLD. Conclusion:The cognitive impairment of LLD patients may be related to microvascular dysfunction.
