Research status on the therapeutic potential of paeoniflorin in renal fibrosis based on the PI3K/Akt/mTOR signaling pathway
10.13699/j.cnki.1001-6821.2025.01.027
- VernacularTitle:基于PI3K/Akt/mTOR信号通路探讨芍药苷治疗肾纤维化的研究现状
- Author:
Lin-zhen JIA
1
;
Tian-tian HAN
;
Li-bo WEN
;
Kun ZHAO
;
Ren-jun GAO
;
Ying LÜ
;
Xue LI
Author Information
1. 齐齐哈尔医学院,药学院,黑龙江 齐齐哈尔 161006
- Publication Type:Journal Article
- Keywords:
paeoniflorin;
traditional Chinese medicine;
renal fibrosis;
phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway
- From:
The Chinese Journal of Clinical Pharmacology
2025;41(1):132-136
- CountryChina
- Language:Chinese
-
Abstract:
The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/Akt/mTOR)signaling pathway plays a crucial role in the regulation of renal fibrosis by participating in inflammatory response,oxidative stress and autophagy.Paeoniflorin exhibits remarkable efficacy in treating myocardial and liver fibrosis.This article provides a comprehensive review on the research progress of paeoniflora in preventing and treating renal fibrosis through modulation of the PI3K/Akt/mTOR signaling pathway,offering novel insights for traditional Chinese medicine-based approaches to prevent and treat renal fibrosis.
