Exploration the role of intestinal flora in drug-induced liver injury based on the gut-liver axis
10.13699/j.cnki.1001-6821.2025.01.024
- VernacularTitle:基于肠-肝轴探讨肠道菌群在药物性肝损伤中的作用
- Author:
Wei ZHOU
1
;
Yue-zhen HE
;
Yan-ling LIU
Author Information
1. 兰州大学第一医院,医学检验中心,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
intestinal flora;
drug-induced liver injury;
gut-liver axis
- From:
The Chinese Journal of Clinical Pharmacology
2025;41(1):116-120
- CountryChina
- Language:Chinese
-
Abstract:
Drug-induced liver injury(DILI)is a common adverse drug reactions in clinical practice,with complex pathophysiological process,the pathogenesis has not been fully elucidated,and lack of objective and specific diagnostic methods and treatment,so the prevention and treatment of DILI has attracted extensive attention from scholars.In recent years,the intestinal flora has become a research hotspot in the field of DILI,and the intestinal flora causes or exacerbates DILI by damaging the intestinal mucosal barrier,affecting the metabolites of the intestinal flora and mediating the immune response,and the gut-liver axis is an important pathway for the intestinal flora to participate in the occurrence of DILI,regulating intestinal flora is practicable in the treatment of DILI.This article reviews the characteristics of intestinal flora in DILI patients,and to explore the possible mechanisms of intestinal flora participating in the pathogenesis of DILI through the gut-liver axis,summarizes the latest progress of intervention in the treatment of DILI by intestinal flora,in order to provide references for the screening of the diagnostic targets of DILI and its prevention and treatment from the perspective of intestinal flora.
