Research progress on the mechanisms of antipsychotic-induced metabolic disturbances
10.3760/cma.j.cn113661-20200615-00270
- VernacularTitle:抗精神病药所致代谢异常的机制研究进展
- Author:
Shu XU
1
;
Yisheng LYU
1
Author Information
1. 华中科技大学同济医学院生理系，武汉 430030
- Publication Type:Journal Article
- Keywords:
Antipsychotic agents;
Metabolic syndrome;
Animal models;
Ghrelin;
Leptin
- From:
Chinese Journal of Psychiatry
2021;54(2):155-159
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic syndrome has become a major health issue in patients with schizophrenia. Antipsychotic medications can induce metabolic disturbances and the features of these metabolic disturbances vary across different drugs and populations. Metabolic side effects of antipsychotic drugs have been duplicated in animal models, in which the translational validity can be influenced by experimental designs. The energy imbalance and change of appetite-regulating hormones may play important roles in antipsychotic-induced metabolic disturbances. This review introduces antipsychotic-induced weight gain and glucose dysregulation and then demonstrates the research progress on animal models and regulating mechanisms of appetite and feeding behaviors and the related problems remained to be explored.
