Acute liver injury induced by alfacalcidol
10.3760/cma.j.issn.1008-5734.2015.01.019
- VernacularTitle:阿法骨化醇致急性肝损伤
- Author:
Shengyu ZHANG
1
;
Xia WANG
;
Ling JIANG
;
Tianlu SHI
Author Information
1. 安徽省立医院药剂科, 合肥,230001
- Publication Type:Journal Article
- Keywords:
Alfacalcidol;
Drug-induced liver injury
- From:
Adverse Drug Reactions Journal
2015;17(1):66-67
- CountryChina
- Language:Chinese
-
Abstract:
A 25-year-old man with chronic renal insufficiency received oral alfacalcidol 0.5 μg every night,compound α-Ketoacid 2.52 g thrice daily,Shengxuening (生血宁) 0.5 g thrice daily,and subcutaneous injection recombinant human erythropoietin 2500 U once every other day.On day 15,laboratory tests showed the following results:alanine aminotransferase (ALT) 411 U/L,aspartate aminotransferase (AST) 341 U/L.He was given an Ⅳ infusion of reduced glutathione 1.2 g once daily.The next day,aminotransferase levels continue to increase,combined with an Ⅳ infusion of polyene phosphatidylcholine 465 mg once daily.On day 20,his liver function reexamination showed the following levels:ALT 1 768 U/L,AST 1 164 U/L,alkaline phosphatase 338 U/L,gamma-glutamyl transferase (γ-GT) 210 U/L.The alfacalcidol was stopped at that day and other drugs were continued.Three days after withdrawal,the levels of ALT,AST,and γ-GT were 644 U/L,206 U/L,and 254 U/L,respectively.Fourteen days later,the level of ALT and AST decreased to 47 U/L and 58 U/L.
