Research status on traditional Chinese medicine regulating cell apoptosis for the treatment of non-small cell lung cancer
10.13699/j.cnki.1001-6821.2025.01.021
- VernacularTitle:中医药调控细胞凋亡治疗非小细胞肺癌的研究现状
- Author:
Si-qi KONG
1
;
Juan CHUAN
;
Jin-tian LI
;
Jian-qing LIANG
;
Yi ZHANG
Author Information
1. 甘肃中医药大学,中医临床学院,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
non-small cell lung cancer;
apoptosis;
death receptor pathway;
mitochondrial apoptosis pathway;
endoplasmic reticulum stress pathway
- From:
The Chinese Journal of Clinical Pharmacology
2025;41(1):100-104
- CountryChina
- Language:Chinese
-
Abstract:
Non-small cell lung cancer(NSCLC)constitutes the largest portion of lung cancer overall,with high incidence and mortality rates.Apoptosis,is a hot focus in the clinical treatment of NSCLC,its main pathways include the extrinsic death receptor pathway,intrinsic mitochondrial apoptosis pathway and endoplasmic reticulum stress pathway,collectively regulating the cellular apoptosis process.Traditional Chinese medicine(TCM)has significant efficacy in the treatment and prognosis of NSCLC,with advantages such as boosting the body's resistance and less adverse drug reactions.Studies have shown that various individual Chinese herbal medicines and compound formulas can treat NSCLC through the apoptosis pathway,alleviating the adverse drug reaction of radiotherapy and chemotherapy.Based on this,this article summarizes recent domestic and international literature,focusing on apoptosis,to summarize the research progress of TCM in treating NSCLC by regulating apoptosis,aiming to provide reference for clinical treatment for NSCLC.
