Functional remediation for euthymic patients with bipolar disorder
10.3760/cma.j.cn113661-20200306-00090
- VernacularTitle:认知矫正对稳定期双相障碍患者的临床疗效
- Author:
Yong ZHANG
1
;
Wenchen WANG
;
Yuanyuan XI
;
Na WANG
;
Dazhi LI
;
Xia SUN
;
Jian ZHANG
;
Shen LI
Author Information
1. 新乡医学院第一附属医院 河南省神经修复重点实验室 453100; 天津市安定医院心境障碍科 300222
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Cognition;
Social function;
Functional remediation;
Emotional recognition
- From:
Chinese Journal of Psychiatry
2020;53(6):486-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the efficacy of functional remediation (FR) on clinical symptoms, emotional recognition and functioning in euthymic patients with bipolar disorder.Methods:The study subjects were randomized into the FR group ( n=39) and the treatment as usual group (TAU, n=42) at the 1∶1 ratio. They were given a 12-week treatment and the emotional recognition, social and cognitive function were assessed at both baseline and the endpoint by Hamilton Depression Rating Scale-17 (HDRS 17), Young Mania Rating Scale (YMRS), Bell-Lysaker Emotion Recognition Task (BLERT), Functioning Assessment Short Test (FAST) and The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB). A chi-square test and independent samples t-test were used to compare the demographic variables and clinical variables between FR group and TAU group, repeated-measures analyses of variances were conducted to compare the impact of two different interventions on clinical symptoms, BLERT emotional recognition, the FAST total scores and six domains, and all domains in MCCB. Results:(1) No differences on baseline demographic variables and clinical variables were found between FR group and TAU group (all P>0.05); (2) The repeated-measures analyses revealed that FR group had greater improvement in the correct numbers of BLERT-negative emotional recognition compared to TAU group ( F=4.53, P<0.05); (3) FR group showed greater improvements in the FAST total scores including occupational functioning and cognitive functioning compared to TAU group ( F=8.15, 7.94, 10.93, all P<0.05); (4) FR group showed greater improvements in the T-scores for TMT-A (Trail Making Test-A), BACS-SC (Brief Assessment of Cognition in Schizophrenia: Symbol Coding subtest), HVLT-R (Hopkins Verbal Learning Test-Revised) and CPT (Continuous Performance Test) compared to TAU group [(41.2±10.2/50.4±6.0) vs. (39.9±9.8/44.2±3.6), (41.8±5.6/52.5±7.4) vs. (40.5±10.4/46.2±4.2), (41.2±4.2/51.7±4.2) vs. (40.0±5.9/46.0±3.2), (41.7±11.1/51.4±5.8) vs. (43.2±8.3/45.7±2.5), F=5.35, 4.94, 8.77, 10.56, all P<0.05]. Conclusions:These findings suggest that FR is a feasible and promising intervention for negative emotional recognition, occupational functioning, ability of verbal learning, attention and information-processing for euthymic patients with BD.
