Research progress on cognitive impairment and genetic inheritance of brain-derived neurotrophic factor in major depressive disorder
10.3760/cma.j.cn113661-20200327-00149
- VernacularTitle:抑郁症认知功能损害与脑源性神经营养因子的基因遗传研究进展
- Author:
Jiali HE
1
;
Shunkai LAI
1
;
Shuming ZHONG
1
;
Yanbin JIA
1
Author Information
1. 暨南大学附属第一医院精神医学科，广州 510630
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Cognition disorders;
Brain-derived neurotrophic factor;
Genetic inheritance
- From:
Chinese Journal of Psychiatry
2021;54(1):45-49
- CountryChina
- Language:Chinese
-
Abstract:
Patients with major depressive disorder (MDD) have a cognitive impairment, and part of the cognitive impairment persists in the remission stage, which restricts the overall patient's comprehensive recovery. Brain-derived neurotrophic factor (BDNF) and its related gene expression play important roles in neuronal genesis, synaptic plasticity and dendritic growth in the brain, and are closely related to the pathogenesis of MDD and its cognitive impairment. Therefore, this article reviews the latest research on the mechanism of cognitive impairment of MDD affected by BDNF from the aspects of gene inheritance, such as BDNF expression, gene polymorphism and epigenetic inheritance, in order to provide a theoretical basis for further exploring the mechanism of cognitive impairment of MDD.
