Personalized combination of treatment options for osteochondral lesions of the talus
- VernacularTitle:距骨骨软骨损伤治疗方案的个性化组合
- Author:
Xueming CHEN
1
;
Chang SHE
Author Information
- Publication Type:Journal Article
- Keywords: talus; osteochondral lesions of the talus; microfracture; transplantation; platelet-rich plasma; stem cell
- From: Chinese Journal of Tissue Engineering Research 2025;29(21):4584-4592
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:For the treatment of osteochondral lesions of the talus,different treatment methods are adopted according to different types or clinical symptoms,including rehabilitation treatment,surgical treatment and biological agent treatment. Most of the rehabilitation treatment relieved the symptoms and delayed the disease in a short time. In recent years,arthroscopic microfractures,kirschner wire drilling,talus cartilage transplantation,autologous osteochondrocyte transplantation,stem cell transplantation,and biological preparation platelet-rich plasma can achieve good results.OBJECTIVE:To summarize the progress in the treatment of osteochondral lesions of the talus and provide a reference for their clinical treatment. METHODS:Using English search terms "talus,osteochondral lesions of the talus" and Chinese search terms "microfracture,transplantation,platelet-richplasma,stem cell," we searched the PubMed and CNKI databases for related articles published from January 2019 to January 2024. A total of 67 articles were included for comprehensive analysis.RESULTS AND CONCLUSION:(1) There are many ways to treat osteochondral lesions of the talus. Conservative rehabilitation and biological agents can alleviate the condition for Hepple type Ⅰ and Ⅱ lesions. Microfracture or Kirschner wire drilling bone marrow stimulation treatment is used for Hepple type Ⅲ and above and lesion diameter<15 mm,but the long-term efficacy is poor. Replacement and regeneration strategies are used for larger lesions,and transplant failure is the main risk. (2) Biological agent treatment is a new treatment method and is often used in combination therapy. (3) In view of the treatment of osteochondral lesions of the talus,many factors such as the area and location of cartilage injury should be taken into account. The selection of the treatment plan should also take into account the level of medical technology,patient acceptance,economic status and other factor. Personalized combination treatment of various schemes is recommended to achieve good results.
