A follow-up study on the changes in salience network function connectivity in clinically cured patients with depression
10.3760/cma.j.cn113661-20200619-00286
- VernacularTitle:临床治愈抑郁症患者脑突显网络功能连接变化的追踪研究
- Author:
Zhenzhen WANG
1
;
Jiaqi ZHONG
;
Hui MA
;
Changjun TENG
;
Yang HAN
;
Hui WANG
;
Ning ZHANG
Author Information
1. 南京师范大学心理学院 210097
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Magnetic resonance imaging;
Salience network;
Clinical cure;
Functional connectivity
- From:
Chinese Journal of Psychiatry
2020;53(5):400-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the change of salience network functional connectivity over time in patients with clinically cured depression.Methods:Twenty-two healthy controls (control group) and 17 clinically cured depressed patients (clinically cured group) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scan at baseline and 6 months later. Routine preprocessing of rs-fMRI data was performed. Salience network was extracted by independent component analysis (ICA) followed by a t-test to compare the differences of salience network functional connectivity between the control group and clinically cured patient group at both baseline and 6 months follow-up. Results were corrected by AlphaSim correction method. Results:At baseline, compared to the control group, clinically cured patient group showed a significantly increased functional connectivity in the dorsolateral prefrontal cortex ( t=2.84, P<0.01, AlphaSim correction) and a significantly increased functional connectivity in the medial prefrontal cortex ( t=4.08, P<0.01, AlphaSim correction) as well as a decreased functional connectivity in the left precuneus ( t=-3.06) and dorsolateral prefrontal cortex ( t=-2.98, P<0.01, AlphaSim correction) at 6 months follow-up. Conclusion:Patient′s functional connectivity of salience network may not stable during the first 6 months after being clinically cured. The abnormal functional connectivity in the dorsolateral prefrontal cortex when they are initially and clinically cured may gradually improve.
