Role of neuropilin 1 in promoting angiogenesis-osteogenesis coupling during fracture healing
10.12307/2025.809
- VernacularTitle:神经纤毛因子1在骨折愈合中促进骨-血管偶联的作用
- Author:
Li ZHENG
1
;
Yiheng DING
;
Xinhao LI
;
Zekai WEN
;
Bingzheng JIANG
;
Xuexia LIN
Author Information
1. 邢台医学院,河北省邢台市 054000
- Publication Type:Journal Article
- Keywords:
neuropilin 1;
fracture healing;
angiogenesis-osteogenesis coupling;
H-type vessel;
endothelial cell;
pericyte;
osteoblast;
osteoclast;
chondrocyte
- From:
Chinese Journal of Tissue Engineering Research
2025;29(21):4576-4583
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Neuropilin 1 plays a critical role in fracture healing,especially in osteogenesis-angiogenesis coupling. Osteogenesis-coupled angiogenesis is vital for fracture healing,including angiogenesis and bone formation (especially H-type vessel formation) and their association. OBJECTIVE:To review the research progress of neuropilin 1 in promoting osteogenesis-coupled angiogenesis during fracture healing.METHODS:The literature search was performed in the PubMed and Chinese National Knowledge Infrastructure databases for articles published from January 1982 to April 2024 using the search terms "Neuropilin-1,neuropilin 1,NRP1,neuropilin-1,NRP-1,Neuropilin 1,Nrp1,Nrp-1." We identified 43 articles associated with fracture healing,H-type vessels,arteries,bone cells,and angiogenesis-osteogenesis coupling. Moreover,24 articles were searched manually. Finally,67 papers were included.RESULTS AND CONCLUSION:(1) Angiogenesis,osteoblastogenesis,and their association were critical for angiogenesis-osteogenesis coupling during fracture healing. Especially H-type vessel formation was critical during fracture healing. H-type vessels consisted of endothelial cells and pericytes. Osteoblasts,osteoclasts,chondrocytes,and other skeletal cells were critical contributors to new bone formation. (2) Neuropilin 1 enhanced endothelial cell migration and stabilization,increased stability of endothelial cells and pericytes,and strengthened the link of endothelial cells and pericytes to initiate angiogenesis by vascular endothelial growth factor and platelet-derived growth factor. (3) Neuropilin 1 promoted bone regeneration by suppressing osteoclastogenesis and enhancing osteoclasts and chondrocyte formation. (4) Neuropilin 1 was a key factor in angiogenesis-osteogenesis coupling. (5) Topical application of neuropilin 1 and relative biologics,and combination neuropilin 1,nano drug-loading systems,and polymerized smart materials provided a new idea for treatment of fractures and hold great promise for extensive applications.
