Study on diffuse tensor imaging of white matter in male alcohol-dependent patients
10.3760/cma.j.cn113661-20200622-00289
- VernacularTitle:男性酒依赖患者脑白质弥散张量成像研究
- Author:
Chuansheng WANG
1
;
Jiali WANG
;
Xiao MA
;
Jiapeng GU
;
Wenhui LI
;
Dandan WEI
Author Information
1. 新乡医学院第二附属医院 453002
- Publication Type:Journal Article
- Keywords:
Alcohol-related disorders;
Diffusion tensor imaging;
White matter
- From:
Chinese Journal of Psychiatry
2020;53(5):414-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Diffusion tensor imaging (DTI) was used to explore the structural integrity of white matter fibers in male alcohol-dependent patients.Methods:DTI scans were performed on 33 male alcohol dependent patients (alcohol dependence group) and 30 healthy adult males (control group). The image data was analyzed by using FSL (Funtional MRI Software Library) software on the Matlab platform, and the two groups were compared based on the TBSS (tract based spatial statistics) method. White matter fiber anisotropy fractional anisotropy (FA) and mean diffusivity (MD) between the two groups were investigated by t test. Results:Compared with the control group, the FA value of the corpus callosum knees decreased (0.55±0.03 vs. 0.58±0.02； t=-3.26, P<0.05), the FA value of the left hippocampus decreased (0.42±0.06 vs. 0.46±0.06； t=-2.69, P<0.05), and the MD value of the left hippocampus increased (122±9 vs. 115±12； t=2.58, P<0.05), the MD value of the left frontal lobe area increased (121±7 vs. 116±11； t=2.50, P<0.05), the MD value of the left frontal bridge bundle increased (122±8 vs. 115±10； t=2.79, P<0.05). Conclusion:Alcohol-dependent patients have abnormal DTI signals representing a damaged structural integrity of white matter fibers in the corpus callosum, hippocampus, and frontal lobe.
