Modeling methods and evaluation criteria in animal models of steroid-induced osteonecrosis of the femoral head
10.12307/2025.190
- VernacularTitle:激素性股骨头坏死动物模型的造模方式和评价标准
- Author:
Xiuli WU
1
;
Xiaoxia YAN
;
Zhiqiang REN
;
Nan SUN
;
Jinju LI
Author Information
1. 河南中医药大学,河南省郑州市 450000
- Publication Type:Journal Article
- Keywords:
steroid-induced osteonecrosis of the femoral head;
histopathology;
animal models;
modeling;
review
- From:
Chinese Journal of Tissue Engineering Research
2025;29(21):4560-4567
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Steroid-induced osteonecrosis of the femoral head is a key risk factor for non-traumatic femoral head necrosis,and the incidence of it has gradually increased in recent years,but its specific pathogenesis is still unclear,and finding a reasonable animal model is essential for disease research and treatment.OBJECTIVE:To review the commonly used animal models of steroid-induced osteonecrosis of the femoral head in recent years,and to analyze the advantages and disadvantages of different modeling methods and evaluation criteria,so as to provide a reference for follow-up research. METHODS:The articles published from 2013 to 2023 were searched in CNKI,WanFang Data,and PubMed with the keywords "femoral head necrosis,osteonecrosis of the femoral head,steroid-induced osteonecrosis of the femoral head,animal model." Finally,61 articles were involved for comprehensive analysis according to the inclusion criteria,including 38 English articles and 23 Chinese articles.RESULTS AND CONCLUSION:(1) Rabbits,rats,and chickens are the animals that are widely used in the study of steroid-induced osteonecrosis of the femoral head models. (2) Hormone combined with lipopolysaccharide or horse serum modeling has low mortality,high success rate,and strong stability. (3) Histopathology is the gold standard for the evaluation model,but the experiment needs to be terminated,which is not conducive to subsequent experimental research,so finding a non-invasive alternative method is still the direction of future efforts. (4) An ideal model of steroid-induced osteonecrosis of the femoral head has not yet been explored,and future researchers need to continue to strive to achieve breakthroughs in this field as soon as possible.
