Acute liver injury due to propacetamol hydrochloride
10.3760/cma.j.issn.1008-5734.2015.02.027
- VernacularTitle:盐酸丙帕他莫致急性肝损伤
- Author:
Siyun YANG
1
;
Zhaoping PAN
;
Yulan HU
;
Hua LIU
;
Longfei WANG
;
Xiaoyan HU
Author Information
1. 637000四川省南充市中心医院临床药学科
- Publication Type:Journal Article
- Keywords:
Propacetamol hydrochloride;
Drug-induced live injury
- From:
Adverse Drug Reactions Journal
2015;(2):155-157
- CountryChina
- Language:Chinese
-
Abstract:
A 45-year-old male received a lump resection on left maxillofacial and cervical region. Before treatment,the laboratory test results were as follows:alanine aminotransferase( ALT)19 U/L, aspartate aminotransferase( AST)32 U/L,gamma glutamyltransferase( GGT)146 U/L. He was given an intravenous infusion of propacetamol hydrochloride 2. 0 g in 0. 9% sodium chloride 100 ml twice daily. The laboratory tests were as follows:alanine aminotransferase 642 U/L,aspartate aminotransferase 692 U/L, gamma glutamyltransferase 368 U/L on day 8 after operation. The patient had no symptoms of nausea, vomiting,abdominal distention,and poor appetite. There was no tenderness in his hepatic zones. He was considered as acute liver injury due to propacetamol hydrochloride. Propacetamol hydrochloride was discontinued immediately and liver-protective drugs such as polyene phosphatidylcholine, reduced glutathione,and N-acetyl cysteine were given. On day 8 of drug withdrawal,the results of laboratory tests were as follows:ALT 87 U/L,AST 341 U/L,GGT 354 U/L. On day 32 of drug withdrawal,the laboratory tests results were as follows:ALT 24 U/L,AST 17 U/L,GGT 36 U/L.
