Research status of p38 mitogen-activated protein kinases signaling pathway in osteosarcoma
10.13699/j.cnki.1001-6821.2025.01.022
- VernacularTitle:p38丝裂原活化蛋白激酶信号通路在骨肉瘤中的研究现状
- Author:
Qing-qing QIN
1
;
Yi-kun WANG
;
Qing-lin YANG
;
Yong-ping WANG
Author Information
1. 兰州大学第一临床医学院,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
p38 mitogen-activated protein kinases;
osteosarcoma;
signaling pathway
- From:
The Chinese Journal of Clinical Pharmacology
2025;41(1):105-110
- CountryChina
- Language:Chinese
-
Abstract:
p38 mitogen-activated protein kinases(p38 MAPK)are involved in the regulation of osteosarcoma(OS)development.Therefore,this paper reviews the current research status of p38 MAPK signaling pathway in OS,mainly including the p38 MAPK signaling pathway regulates the biological behaviors of OS such as proliferation,migration,invasion,apoptosis,autophagy,iron death,angiogenesis and epithelial-mesenchymal transition(EMT),and non-coding RNAs and oxidative stress are involved in the development of OS through the modulation of p38 MAPK signaling pathway.reviewed to provide new ideas for finding the treatment of OS.
