Death from malignant hyperthermia due to halothane combined with succinylcholine chloride
10.3760/cma.j.issn.1008-5734.2015.02.29
- VernacularTitle:氟烷与氯化琥珀胆碱联用致恶性高热死亡
- Author:
Tailiang WANG
1
;
Zhiyi QIN
Author Information
1. 063000,河北省唐山市药品检验所
- Publication Type:Journal Article
- Keywords:
Halothane;
Succinylcholine;
Malignant hyperthermia
- From:
Adverse Drug Reactions Journal
2015;(2):159-160
- CountryChina
- Language:Chinese
-
Abstract:
A 36-year-old male underwent local resection of hemangioma of liver under general anesthesia. Physical examination showed the following results:body temperature was 36. 0 ℃,heart rate 71 beats/min,breathing rate 14 breathes/min,blood pressure 120/82 mmHg. The patient received induced anesthesia with 1. 5% halothane. And then received intravenous administration of midazolam,esmolol, propofol,remifentanil,suxamethonium chloride,and vecuronium bromide,successively. The patient's hepatic hemangioma was resected smoothly. He developed high fever(40℃),his heart rate was 140 beats/min,blood pressure 96/52 mmHg 90 minutes later. The anaesthetist considered as malignant hyperthermia due to halothane combined succinylcholine chloride. Halothane was withdrawn immediately. He underwent comprehensive treatments immediately,including physical cooling;correcting acidosis,hyperkalemia,and arrhythmia;elevating blood pressure;diuresis,protection of renal function,and synchronous direct current cardioversion. The patient developed ventricular tachycardia, arrhythmia, cardiac arrest, and high temperature( >42 ℃),successively during the treatment. Finally,the patient died despite resuscitation attempts about 3 hours after malignant hyperthermia occurred.
