Differences of resting-state functional magnetic resonance imaging and cognitive function between depressive and schizophrenic patients
10.3760/cma.j.cn113661-20200621-00287
- VernacularTitle:抑郁症与精神分裂症患者静息态功能磁共振成像与认知功能的差异
- Author:
Cheng CHEN
1
;
Huiling WANG
;
Gaohua WANG
;
Tianzi JIANG
;
Yuan ZHOU
;
Huan HUANG
;
Shihao WU
;
Bei RONG
Author Information
1. 武汉大学人民医院精神科 430060
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Schizophrenia;
Magnetic Resonance Imaging;
Cognition
- From:
Chinese Journal of Psychiatry
2020;53(5):377-383
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the characteristics and correlation of brain activity and cognitive function between depression and schizophrenia.Methods:36 normal controls (NC), major depression disorder (MDD) and schizophrenia (SZ) patients participated in this study. Digital symbol test (DST), digital span test (DSPT), and verbal fluency test (VFT) were performed. All subjects underwent resting-state fMRI. Routine preprocessing of resting-state fMRI data was performed. The regional homogeneity (ReHo) and fractional amplitude of low frequency fluctuation(fALFF) values were calculated. Cognitive function assessment and brain functional activity characteristics were compared among the three groups. Pearson correlation was used to analyze the correlation between cognitive impairment and brain functional activity.Results:(1) Compared with NC （68.75±10.40, 9.22±1.07, 5.95±1.67, 22.39±4.53）, DST, DSPT and VFT scores decreased in MDD (60.86±10.75, 8.06±0.80, 5.19±1.12, 19.36±2.85） and SZ (46.64±9.50, 7.50±0.91, 4.08±1.05, 14.86±3.78).The decline was more significant in the schizophrenia group （ F=2.39, 1.43, 1.52, 2.16, P<0.01）. (2) Significant differences of the ReHo values in the three groups were all in the left lentiform nucleus-insula-Roland′s island ( F=22.1, P<0.001, AlphaSim correction, voxel number>99), with higher ReHo value in MDD, while lower in SZ. Significant differences of fALFF value in the three groups were in the left superior parietal areas and bilateral insula-lentiform nucleus ( F=28.46, 13.12, P<0.001, AlphaSim correction, voxel number>90). Compared with MDD and NC, SZ showed higher fALFF value in the left superior parietal areas and the bilateral insula-lentiform nucleus （ P<0.05）.(3) The results of correlation analysis showed that DST score of MDD was negatively correlated with ReHo value in the left lentil-insula region ( r=-0.38, P=0.02). DSPT score was negatively correlated with fALFF value in insula-lentiform nucleus in SC ( r=-0.39, P=0.02). Conclusion:The cognitive impairment of schizophrenia is more serious than that of depression; Abnormal activity of parietal lobe, insula and striatum can be prominent in both depressive and schizophrenias patients, and the three brain regions might be the key locations that distinguish schizophrenia from depression in terms of the cognitive impairment.
