Comparison of the effects between venlafaxine and fluoxetine in relieving somatic pain symptoms of postmenopausal depression patients
10.3760/cma.j.cn113661-20200421-00189
- VernacularTitle:文拉法辛和氟西汀对绝经后抑郁症患者躯体疼痛症状8周疗效的对照研究
- Author:
Xiao WANG
1
;
Rui YANG
;
Gang WANG
;
Yongdong HU
;
Jingjing ZHOU
Author Information
1. 首都医科大学附属北京安定医院 国家精神心理疾病临床医学研究中心 精神疾病诊断与治疗北京市重点实验室 100088
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Postmenopausal;
Somatic pain;
Randomized controlled trial
- From:
Chinese Journal of Psychiatry
2020;53(4):295-299
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of venlafaxine and fluoxetine for somatic pain symptoms in postmenopausal depression patients.Methods:In an 8-week randomized controlled study, 184 postmenopausal depression patients who met the study criteria were randomly assigned into the venlafaxine group (90 cases) and the fluoxetine group (94 cases). 172 patients were divided into full analysis set(FAS) and 184 patients were divided into safety set (SS).The efficacy was assessed by the Visual Analogue Scale (VAS), Clinical Global Impression-Severity (CGI-S), and HAMD 24 at baseline, 1-week, 2-week, 4-week, 6-week and 8 weeks treatment. Mixed-effect model repeated measure (MMRM), paired sample t test and independent sample t test were used to compare the efficacy between the two groups. Results:(1) MMRM analysis showed that the main effect of VAS scores between groups was statistically significant, venlafaxine group was significantly lower than the fluoxetine group ( F=6.89, P=0.001).(2) The anxiety/somatization scores and CGI-S scores at 1-week, 2-week, 4-week, 6-week and 8 weeks treatment were significantly lower than baseline（all P<0.05) in both groups. The anxiety/somatization scores of the venlafaxine group were statistically lower than the fluoxetine group at 1-week, 2-week, 4-week, 6-week and 8 weeks treatment ( t=-2.66, 2.21, -3.52, -4.10, -3.14, all P<0.05). The CGI-S scores of venlafaxine group were lower than fluoxetine group at 4-week, 6-week and 8 weeks treatment( t=-2.73, -2.08, -2.17, all P<0.05). (3)There was no significant difference in the incidence of adverse reaction between the two groups (χ 2=0.61, P=0.434). Conclusion:Venlafaxine is more effective in the treatment of somatic pain symptoms in postmenopausal depression than fluoxetine.
